Genetically prolonged beige fat in male mice confers long-lasting metabolic health
Abstract A potential therapeutic target to curb obesity and diabetes is thermogenic beige adipocytes.However, beige adipocytes quickly transition into white adipocytes upon removing stimuli.Here, we define the critical role of cyclin dependent kinase inhibitor 2A (Cdkn2a) as a molecular pedal for the beige-to-white transition.Beige adipocytes lacki